Reply to the letter to the editor 'Journey to a faraway land' by Alkan et al.
نویسندگان
چکیده
supporting its role in CRC metastatic development [1]. However, the precise status of miR-29c in metastatic CRC tissues is a major question to be fully investigated. Thus, we quantified miR-29c in primary and paired metastatic tissues from 17 CRC patients, 12 with liver metastasis and 5 with lung metastasis, using Taqman Low Density Arrays (TLDAs) panel A (Applied Biosystems). A pathologist reviewed the specimens to further confirm the diagnosis. All samples were taken anonymously and the ethical committee and institutional review board approved the project. Relative gene expression analysis was carried out using the 2 method and U6B as internal control. We observed similar miR-29c expression between primary and metastatic tissues from those 12 CRC patients with liver metastasis. However, almost threefold increased miR-29c levels were found in the metastatic tissues of those cases with lung metastasis. We then investigated whether these differences were due to expression changes in the primary tissues or dependent on the metastatic site. Interestingly, miR-29c showed significantly lower expression in primary CRC tissues from patients with lung metastasis compared with those cases with liver metastasis (P = 0.046). No differences were observed when comparing miR-29c between liver and lung CRC metastatic tissues (P = 0.934). In summary, our results would indicate that deeper miR-29c downregulation would be required in the premetastatic CRC cell to develop lung metastasis than liver metastasis. In addition, the potential predictive value of miR-29c determining the CRC metastatic niche should be further confirmed in forthcoming studies.
منابع مشابه
Environmental gamma radiation: a comment (Letter to the Editor)
Editor, I read the recent publication by Toossi et al. with a great interest (1). Toossi et al. concluded that “Average gonad and bone marrow doses for North Khorasan, Boshehr and Hormozgan provinces were less than the corresponding values for normal area (2).” There are some facts on this report to be concerned. I agree that the detected levels might be high in the mentioned area, but th...
متن کاملLetter to editor
Dear Prof. Mozdarani,I would like to discuss about some important aspects regarding the article published in, "Iran. J. Radiat. Res., 2012 10(2): 89-94“ with title of “Patient doses from X-ray computed tomography examinations by a single-array detector unit: Axial versus spiral mode" by Ghavami et al. (1), so according to journal policy and in suitable manner please ask the authors to rep...
متن کاملComment to the Letter to the Editor: Subjective Symptoms Related to GSM Radiation from Mobile Phone Base Stations: a cross-sectional study In reply to the comments by Seyed Mohammad Javad Mortazavi
متن کامل
Administration of Magnesium Sulfate to Women with Premature Labor: The Effect on Bleeding Time
Dear Editor, I read with interest the article by Yazdani, M, et al, on the administration of magnesium sulfate to women with premature labor and its effect on the bleeding time, published in the Iranian Journal of Medical Sciences.1I found it interesting but I would like to make some points regarding to this study:There are several methods for the measurement of bleeding time (BT). Those includ...
متن کاملLetter to the editor on "The Relationship between Sitting Posture and Musculoskeletal Pain in Boy Elementary School Students" by Saeed Ilbeigi et al.
The expanding developments in medical sciences indicate that it is necessary to emphasize compliance with religious, legal, and ethical standards in research, especially human research, and to collect and maintain information to preserve human health and dignity. As stated in the basic principles of the journal, research should be organized based on the Helsinki Declaration and in compliance wi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Annals of oncology : official journal of the European Society for Medical Oncology
دوره 26 10 شماره
صفحات -
تاریخ انتشار 2015